Never underestimate dysentery; it killed half the royalty in England. (The "A History of Britain" drinking game: take a drink every time an aristocrat dies of dysentery.)
People old enough to not have played Oregon Trail would have been introduced to computers at a point late enough that there would have been more than 3 games for them, so there wouldn't be one game they're all familiar with.
My most vivid memory of Oregon Trail is naming my entire party after childish dirty words and seeing "Your Dick has died of a snake bite" alongside a picture of settlers weeping over a grave.
stopped this after 10 seconds. HAHA Oregon Trail remember that game!??????!! Ownage, lets make a video of it with a lot of money to draw hipster to our website! OWNAGE