AND I saw Eugene Mirman when he was in college at the campus coffee shop open mic.

I concur.

There's an urban legend that the five colleges in the area were models for the Scooby Doo gang. Velma and Daphne are Smith/Holyoke, Fred is Amherst (private preppy school), Shaggy is Hampshire (like, roll your own major, man), and Scooby is Umass (zoo mass).

They all fit.

Does that make Emerson the evil Mr. Wickles and Berklee the Mystery Mobile?

The urban legend was repeated over and over again while I was there. Credence was lent to it because part of the story was that Scooby Doo was created by an Amherst grad (did Ruby or Spears go there? I have no idea), but some of the show's writers have said the myth is false.

Emerson and Berkleee are nowhere near the five colleges area, but if you can write a convincing backstory, I'll buy it.

With a very passive interest in this subject, it took seconds to discover that Scooby Doo is older than Hampshire College. So good job, urban legends.